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The 15th international symposium on proteomics in the life sciences

Aug. 17–21, 2025
Broad Institute of MIT and Harvard, Cambridge, Mass.

Boston skyline

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This five-day symposium will be an international forum for discussion of the remarkable advances in cell and human protein biology revealed by ever-more-innovative and powerful proteomics technologies.

Formerly known as the "International symposium on mass spectrometry in the health and life sciences," the meeting has been renamed to reflect the growing number of partial and non-mass spectrometry–based methods under discussion.

The symposium will juxtapose sessions about methodological advances with sessions about the roles those advances play in solving problems and seizing opportunities to understand the composition, dynamics and function of cellular machinery in numerous biological contexts. In addition to celebrating these successes, we also intend to articulate urgent, unmet needs and unsolved problems that will drive the field in the future.

In addition to talks by invited plenary and session speakers, short talks will be selected from submitted abstracts. See the program of our previous meeting.

Themes

  • Sunday minisymposium — Data-independent acquisition: current status and the road ahead 
  • Sample preparation and automation
  • Instrumentation and data generation
  • Emerging technologies: Single cell and spatial proteomics
  • Proteomics in structural biology and integration with other high resolution methods
  • Interactomics: Understanding pathways, networks and molecular machines
  • Chemical biology and chemoproteomics: Toward functional understanding of drugs and their targets
  • Cell, organellar and tissue biology: Signaling, cross talk and communication
  • Impact of clinical and translational proteomics in human health and treatment
  • Multiomics integrative analysis and the emerging roles of machine learning and neural models

Important dates

June 9 Abstract deadline
June 18 Early registration deadline
July 23 Regular registration deadline

Organizers

University of California, San Francisco
Steven Carr Broad Institute of MIT and Harvard
Ileana Cristea Princeton University
Technical University of Munich
University of Cambridge


Brought to you and organized by .

Sponsors

Sponsorship opportunities

The symposium will offer a variety of sponsorship opportunities for your organization to optimize their visibility to attendees. Learn about sponsorship opportunities

Plenary speakers

Pedro Beltrao

Pedro Beltrao
Institute of Molecular Systems Biology, ETH Zurich

Alessio Ciulli

Alessio Ciulli
University of Dundee

Ileana Cristea

Ileana Cristea
Princeton University

Connie Jimenez

Connie Jimenez
VU University Medical Center

Michael MacCoss

Michael MacCoss
University of Washington

Shira Weingarten–Gabbay

Shira Weingarten–Gabbay
Harvard Medical School

Partial list of speakers

  • Jenn Abelin, Broad Institute of MIT and Harvard
  • Theodore Alexandrov, University of California, San Diego
  • Lotte Bjerre Knudsen, Novo Nordisk
  • Natalie Clark, Broad Institute of MIT and Harvard
  • Fabian Coscia, Max Delbrück Center
  • Jürgen Cox, Max Planck Institute of Biochemistry
  • Katherine Donovan, Harvard Medical School
  • Will Freed–Pastor, Dana-Farber Cancer Institute
  • Martin Frejno, MSAID GmbH
  • Rebekah Gundry, University of Nebraska Medical Center
  • Tiannan Guo, Westlake University
  • Kallol Gupta, Yale University
  • Nir Hacohen, Massachusetts General Hospital
  • Albert Heck, Utrecht University
  • Ruth Huttenhain, Stanford University
  • Martin F. Jarrold, Indiana University
  • ³¢³Ü°ì²¹²õ&²Ô²ú²õ±è;°­Ã¤±ô±ô, KTH Royal Institute of Technology
  • Manuel Leonetti, Chan Zuckerberg Biohub Network
  • Elizabeth Lightbody, Dana-Farber Cancer Institute
  • Kathryn Lilley, University of Cambridge
  • Fan Liu, Leibniz-Forschungsinstitut for Molecular Pharmacology
  • Emma Lundberg, SciLifeLab
  • Corinne Lutomski, University of Oxford
  • Tony Ly, University of Dundee
  • Johannes Mueller–Reif, Max Planck Institute of Biochemistry
  • Thierry Nordmann, Max Planck Institute of Biochemistry
  • Francis O’Reilly, National Cancer Institute
  • Jesper Olsen, Novo Nordisk Foundation Center for Protein Research
  • Monika Pepelnjak, Institute of Molecular Systems Biology
  • Kelly Ruggles, New York University
  • Mikhail Savitski, European Molecular Biology Laboratory
  • Birgit Schilling, Buck Institute
  • Ludwig Sinn, Technical University of Berlin
  • Olga Vitek, Northeastern University
  • Georg Wallmann, Max Planck Institute of Biochemistry
  • Bruce Wilcox, PrognomiQ
  • Mathias Wilhelm, Technical University of Munich
  • Mike Yaffe, Massachusetts Institute of Technology
  • Fengchao Yu, University of Michigan
  • Yingming Zhao, University of Chicago

Registration

ASBMB members will receive a $50 discount on their registration fee which will be applied during checkout. Not a member? Join ASBMB and save!

 
  Early registration
(by June 18)
Regular registration
(by July 23)
PI/regular academics, industry or equivalent $800 $850
Graduate student, postdoc or equivalent $450 $500

NOTE: Registration is on a first come, first served basis and will remain open until capacity is reached. This may mean that the conference registration closes before the officially posted registration deadline. To secure your spot at the conference, we encourage you to register early.

What’s included

  • All sessions, poster sessions and meeting materials for both the mini-symposium and the main symposium.
  • Networking refreshment breaks.

Note: Lodging is not included in the registration rates.

Registration changes

Registration changes will be accepted as space allows until July 23, 2025, and can be made by contacting meetings@asbmb.org.

Cancellation policy

Cancellations received in writing on or before July 23, 2025, are subject to a $100 processing fee. No refunds will be issued for cancellations after July 23 due to final guarantee commitments. Email meetings@asbmb.org and attach a copy of your meeting registration receipt/paid invoice to cancel your registration.

Location

The Broad Institute of MIT and Harvard
415 Main Street
Cambridge, MA 02142

Airport

– 5 miles

Parking at the Broad Institute

“The Yellow Parking Garage” can be reached by an unnamed access road off of Ames Street or Galileo Way (between Broadway and Main Street). Upon entering the garage, take a ticket from the machine.

Health & Safety

Mask-wearing and other health and safety measures will be determined based on local, state, and venue guidelines and will be communicated to attendees prior to the conference.

Visas

All individuals traveling from outside of the United States should apply for a visa as soon as possible and at least four to five months prior to their date of travel.

  • The most up-to-date information about traveling to the U.S. can be found at the .
  • Scientists visiting the U.S. may find helpful information at the .
  • .

Please do not wait until you receive your registration confirmation before applying for a visa. We encourage you to apply for your visa right away if you are considering attending to avoid delays and longer than anticipated wait times.

If you need a letter of invitation for your visa process, please email meetings@asbmb.org.

  • Please include ‘LETTER OF INVITATION’ as the subject line of this email.
  • Body of email must include:
    • Your name as it appears on your passport
    • Your affiliation and mailing address
    • Best contact number and email address

Program schedule

Saturday August 16
Sunday August 17
Monday August 18
Tuesday August 19
Wednesday August 20
Thursday August 21

Saturday agenda

3:00 PM - 6:00 PM

Badge pickup

Sunday agenda

7:00 AM - 7:00 PM

Badge pickup

8:15 AM - 8:30 AM

Mini-symposium opening remarks

8:30 AM - 9:30 AM

Plenary talk

Motif-based approaches for analyzing phosphoproteomic mass spectrometry datasets identify signaling dependencies in cancers lacking known oncogenic drivers
Michael MacCoss, University of Washington
10:00 AM - 10:30 AM

Networking break

10:30 AM - 12:00 PM

Sessions

Double dipping: Confirmation bias inflates DIA data completeness
Martin Frejno, MSAID GmbH
Accelerated and sensitive library-free DIA immunopeptidomics using Kuiper: A novel search strategy for class I and II peptides
Monika Pepelnjak, Biognosys
Spectrum-centric and indexing approaches for DIA proteomics in FragPipe
Fengchao Yu, University of Michigan
Aging and senescence protein signatures in human ovary, muscle and lung tissues across the life span
 
Birgit Schilling, Buck Institute for Research on Aging
12:00 PM - 1:30 PM

Lunch on your own

1:30 PM - 5:30 PM

Afternoon session

Large-scale protein concentration profiling with MaxQuantAtlas
Jürgen Cox, Max Planck Institute of Biochemistry
De novo sequencing of MS2s and Cryo-EM maps
Lukas Käll, KTH Royal Institute of Technology
High-throughput perturbation proteomics with DIA for construction of AI virtual cells
Tiannan Guo, Westlake University
Statistical methods increase the accuracy and the interpretability of quantitative proteomic investigations
Olga Vitek, Northeastern University
The synergy of identification and quantification quality for modern DIA proteomics
Ludwig Sinn, Technical University of Berlin
Leveraging transfer learning to advance DIA proteomics
Georg Wallman, Max Planck Institute of Biochemistry
DIA analysis of protein turnover and abundance in single cells
Jesper Olsen, Novo Nordisk Foundation Center for Protein Research
3:00 PM - 3:30 PM

Networking break

5:30 PM - 7:30 PM

Opening reception

Sponsored by Thermo Fisher

Monday agenda

7:00 AM - 5:00 PM

Badge pickup

8:15 AM - 8:30 AM

Opening remarks

8:30 AM - 9:30 AM

Plenary session

Shedding light on the dark viral proteome to advance our understanding of antiviral immunity
Shira Weingarten–Gabbay, Harvard Medical School
9:30 AM - 11:30 AM

Morning session

Charge detection mass spectrometry for viruses, vaccines and particles: Mass spectrometry in the megadalton regime
Martin Jarrold, Indiana University
10:00 AM - 10:30 AM

Networking break

11:30 AM - 12:30 PM

Poster flash talks

12:30 PM - 2:00 PM

Lunch on your own

2:00 PM - 4:00 PM

Afternoon session

Spatial tissue proteomics across scales and diseases
Fabian Coscia, Max Delbrück Center
Prosit-PTM: Zero-shot deep learning enables confident detection and localization of unseen post-translational modifications
Mathias Wilhelm, Technical University of Munich
Spatial proteomics for precision medicine in dermatology
Thierry Nordmann, Max Planck Institute of Biochemistry
4:00 PM - 6:00 PM

Poster session I and refreshments

Tuesday agenda

7:00 AM - 5:00 PM

Badge pickup

8:15 AM - 8:30 AM

Opening remarks

8:30 AM - 9:30 AM

Plenary session

Protein degraders: New insights and twists of molecular mechanism and drug design
Alessio Ciulli, University of Dundee
9:30 AM - 11:30 AM

Morning session

Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics
Katherine Donovan, Harvard Medical School
TBD
Rebekah Gundry, University of Nebraska Medical Center
Defining proteoform-specific interactions for drug targeting in a native cell signaling environment
Corinne Lutomski, University of Oxford
10:00 AM - 10:30 AM

Networking break

11:30 AM - 12:30 PM

Poster flash talks

12:30 PM - 2:00 PM

Lunch on your own

2:00 PM - 4:00 PM

Afternoon session

Nanoscale molecular cartography of the cellular membranes
Kallol Gupta, Yale University
Exploring non-canonical GPCR interactions using unbiased proteomics
Ruth Huttenhain, Stanford University
Biophysical proteomics
Mikhail Savitski, European Molecular Biology Laboratory
Intracellular cartography of the human proteome
Manuel Leonetti, Chan Zuckerberg Biohub Network
4:00 PM - 6:00 PM

Poster session II and refreshments

Wednesday agenda

7:00 AM - 6:00 PM

Badge pickup

8:15 AM - 8:30 AM

Opening remarks

8:30 AM - 9:30 AM

Plenary session

Studying the mechanisms and cellular processes regulated by protein post-translational modifications
Pedro Beltrao, Institute of Molecular Systems Biology, ETH Zurich Laboratory
9:30 AM - 12:30 PM

Morning session

Touching upon the millions of hidden treasures in the plasma proteome
Albert Heck, Utrecht University
Approaches to sampling the subcellular proteome
Kathryn Lilley, University of Cambridge
Breaking the cycle: mechanisms that underpin proliferation–dormancy switches
Tony Ly, University of Dundee
The lysine L-lactylation pathway: Biochemistry, epigenetics and pathophysiology
Yingming Zhao, University of Chicago
10:00 AM - 10:30 AM

Networking break

12:30 PM - 2:00 PM

Lunch on your own

2:00 PM - 4:00 PM

Sessions

Motif-based approaches for analyzing phosphoproteomic mass spectrometry datasets identify signaling dependencies in cancers lacking known oncogenic drivers
Michael Yaffe, Massachusetts Institute of Technology
Sensitive direct detection of MHC-associated cancer antigens enabled by user defined peptide libraries
Jenn Abelin, The Broad Institute of MIT and Harvard
Decoding human cell architecture — from spatial proteomics to cell modeling
Emma Lundberg, SciLifeLab
3:30 PM - 5:30 PM

Poster session 3 and refreshments

6:30 PM - 9:00 PM

Conference reception

Thursday agenda

7:30 AM - 3:00 PM

Badge pickup

8:15 AM - 8:30 AM

Opening remarks

8:30 AM - 9:30 AM

Plenary session

Phosphoproteomics as a functional molecular read-out for personalized precision oncology
Connie Jimenez, VU University Medical Center
9:30 AM - 12:30 AM

Morning session

Unlocking the potential of untargeted plasma proteomics for lung cancer: Translating discovery to a liquid biopsy LDT
Bruce Wilcox, PrognomiQ
Comprehensive characterization of the plasma proteome of patients with multiple myeloma and its precursor conditions and identification of a predictive high-risk signature of disease progression
 
Elizabeth Lightbody, Dana-Farber Cancer Institute
A scalable framework for translational plasma proteomics: From population-based discovery to direct diagnostic application
Johannes Mueller–Reif, Max Planck Institute of Biochemistry
Proteogenomic pancancer interrogation of the ubiquitin proteosome system
Kelly Ruggles, New York University
Cryptic antigens: Novel targets in pancreas cancer
 
Will Freed–Pastor, Dana-Farber Cancer Institute
10:00 AM - 10:30 AM

Networking break

10:30 AM - 12:30 AM

Sessions

Intrinsic and extrinsic control of STING activities
Nir Hacohen, Massachusetts General Hospital
Mechanistic insights and omics-driven exploration of GLP-1 receptor agonist therapeutics
Lotte Bjerre Knudsen, Novo Nordisk
12:30 PM - 2:00 PM

Lunch on your own

3:30 PM - 4:30 PM

Plenary session

The interface between metabolism and immunity within a virus microenvironment
Ileana Cristea, Princeton University
4:30 PM - 5:00 PM

Closing remarks, discussion and adjourn

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